Herb Garden

Cognitive Performance and Stress Adaptation
Classed primarily as an adaptogen, E. senticosus acts to normalize body functions under stress, specifically via the hypothalamic-pituitary-adrenal (HPA) axis. Active constituents, particularly eleutherosides B and E, have been shown to improve mental acuity and physical endurance during periods of fatigue. [1,2] In the context of focus and concentration, it helps mediate the "alarm phase" of the stress response, preventing adrenal burnout and allowing for sustained attention. [3] Studies involving subjects suffering from chronic fatigue showed significant improvements in mental health and cognitive performance scores compared to placebo. [4] Furthermore, specific research on elderly patients demonstrated that supplementation resulted in measurable improvements in social functioning and mental health, suggesting a restorative effect on cognitive vitality. [5]

Neuroprotection and Physical Stamina
Beyond immediate focus, Siberian Ginseng supports the underlying biological machinery required for concentration. It exhibits neuroprotective properties, specifically by inhibiting microglial activation and neuroinflammation, which are often precursors to cognitive decline. [6,7] In terms of energy metabolism—crucial for a "focus" product—extracts have been shown to enhance lipid metabolism and reduce the buildup of lactic acid and blood urea nitrogen (BUN), effectively delaying physical and mental exhaustion. [8] This increase in work capacity allows for longer periods of productive activity without the "crash" associated with stimulants. [9]

Toxicity
Classed as having a high safety profile with very low toxicity. Acute toxicity studies in mice established an LD50 of over 25,000 mg/kg, indicating it is virtually non-toxic in standard doses. [10] Long-term administration studies (up to 6 months) in rats showed no histological changes in major organs or signs of toxicosis. [11] No teratogenic or embryotoxic effects have been observed. [12] However, caution is usually advised for individuals with extremely high blood pressure (180/90+) during acute phases. [13]