Herb Garden

Anxiolytic Effects and Sleep Architecture
Lavender has transitioned from a traditional folk remedy to a clinically validated treatment for anxiety and sleep disorders. The primary mechanism of action is attributed to the monoterpenes linalool and linalyl acetate, which appear to inhibit voltage-gated calcium channels (VGCCs) in the central nervous system, reducing neurotransmitter release in a manner similar to pregabalin but without the associated sedation or potential for abuse. [1,2] Clinical trials utilizing standardized oral lavender preparations have demonstrated efficacy comparable to low-dose benzodiazepines (such as lorazepam) in generalized anxiety disorder (GAD), resulting in significant reductions in HAMA scores. [3,4] Furthermore, lavender has been shown to improve sleep architecture by increasing the percentage of deep slow-wave sleep, leading to higher reported vigor upon waking. [5]

Neuroprotection and Mood Regulation
Beyond its calming effects, lavender exhibits neuroprotective potential through antioxidant mechanisms. In vitro and in vivo studies suggest that lavender oil protects neuronal cells from neurotoxicity and oxidative stress, potentially mediated by the upregulation of endogenous antioxidant enzymes. [6,7] regarding mood modulation, research indicates that lavender may interact with the serotonergic system (5-HT1A receptors), offering a synergistic effect when used alongside standard antidepressant therapies. [8] Additionally, the inhalation of lavender has been shown to significantly decrease cortisol levels and increase alpha wave activity in the brain, correlating with a state of relaxed alertness and improved cognitive processing during stress. [9]

Toxicity
Classed as Generally Recognized As Safe (GRAS) for food use. Toxicity studies indicate a high safety margin; oral LD50 values in rats are reported to be >5g/kg. [10,11] Adverse effects in human clinical trials are generally mild and transient, primarily limited to gastrointestinal disturbances (eructation). [12] Unlike benzodiazepines, lavender does not appear to cause withdrawal symptoms or dependence. However, caution is advised regarding potential estrogenic activity in high concentrations of topical applications, though this is rarely relevant to dietary supplementation. [13]