Herb Garden

Neurotransmitter Synthesis and Cognitive Support
Calcium Pantothenate is the stable calcium salt of Vitamin B5, a critical precursor for the synthesis of Coenzyme A (CoA). In the brain, CoA is the essential cofactor required to acetylate choline, resulting in the formation of Acetylcholine—the primary neurotransmitter associated with memory, learning, and attention. [1] Without adequate levels of pantothenic acid, the production of Acetylcholine is rate-limited, potentially impacting cognitive processing speed and focus. Clinical reviews suggest that B-complex vitamins, specifically B5, play a vital role in preserving cognitive function and modulating mental fatigue during demanding tasks. [2,3]

Cellular Energy and Stress Adaptation
Beyond its neurological role, Calcium Pantothenate is fundamental to human bioenergetics. As a component of CoA, it acts as an acyl-group carrier essential for the Tricarboxylic Acid (TCA) cycle (Krebs cycle), facilitating the breakdown of carbohydrates and lipids into Adenosine Triphosphate (ATP)—the cell’s energy currency. [4] Furthermore, high concentrations of pantothenic acid are found in the adrenal cortex, where it supports the synthesis of steroid hormones (such as cortisol). This interaction suggests a supportive role in the body’s physiological response to stress, maintaining metabolic homeostasis during periods of high physical or mental exertion. [5]

Toxicity
Classed as Generally Recognized As Safe (GRAS) for food use. Calcium Pantothenate is water-soluble, meaning excess amounts are typically excreted via urine rather than accumulated in adipose tissue, resulting in a very high safety profile. No specific Upper Tolerable Intake Level (UL) has been established due to the lack of observed toxicity in standard widespread use. [6] Adverse effects are rare and typically limited to mild gastrointestinal distress (diarrhea) only at extremely high doses exceeding 10g per day. [7]